2-Fluorobenzoyl chloride → HCID 59401822, compound

HRID 1916913Notes

Reaction equation

HRID 1916913 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:12][CH2:11][CH:10]([N:13]3[CH2:17][CH2:16][CH2:15][C@H:14]3[CH3:18])[CH2:9]2)[CH:5]=[CH:4][C:3]=1[NH2:19].[F:20][C:21]1[CH:29]=[CH:28][CH:27]=[CH:26][C:22]=1[C:23](Cl)=[O:24]>>[F:20][C:21]1[CH:29]=[CH:28][CH:27]=[CH:26][C:22]=1[C:23]([NH:19][C:3]1[CH:4]=[CH:5][C:6]([N:8]2[CH2:12][CH2:11][CH:10]([N:13]3[CH2:17][CH2:16][CH2:15][C@H:14]3[CH3:18])[CH2:9]2)=[CH:7][C:2]=1[CH3:1])=[O:24]

Participants

3

Reactant 2

HCID 98082-Fluorobenzoyl chlorideHCID 594017832-methyl-4-(2-(R)-methyl-[1,3']bipyrrolidinyl-1'-yl)-phenylamine

Product 1

HCID 59401822HCID 59401822, compound

Procedure

The title compound was prepared in a manner substantially the same as Example 1 by coupling 2-methyl-4-(2-(R)-methyl-[1,3′]bipyrrolidinyl-1′-yl)-phenylamine with 2-fluorobenzoyl chloride. LCMS: RT=1.70 minutes, MS: 382 (M+H).

Sources & evidence

ORD record
ord-c2fd93dd2d744885a76ee86c47681f57
Source dataset
uspto-grants-2013_12
Patent number
US08618159B2

Reaction notes

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