4-Fluorobenzoyl chloride → HCID 59401754, compound

HRID 1916914Notes

Reaction equation

HRID 1916914 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:12][CH2:11][CH:10]([N:13]3[CH2:17][CH2:16][CH2:15][C@H:14]3[CH3:18])[CH2:9]2)[CH:5]=[CH:4][C:3]=1[NH2:19].[F:20][C:21]1[CH:29]=[CH:28][C:24]([C:25](Cl)=[O:26])=[CH:23][CH:22]=1>>[F:20][C:21]1[CH:29]=[CH:28][C:24]([C:25]([NH:19][C:3]2[CH:4]=[CH:5][C:6]([N:8]3[CH2:12][CH2:11][CH:10]([N:13]4[CH2:17][CH2:16][CH2:15][C@H:14]4[CH3:18])[CH2:9]3)=[CH:7][C:2]=2[CH3:1])=[O:26])=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 678794-Fluorobenzoyl chlorideHCID 594017832-methyl-4-(2-(R)-methyl-[1,3']bipyrrolidinyl-1'-yl)-phenylamine

Product 1

HCID 59401754HCID 59401754, compound

Procedure

The title compound was prepared in a manner substantially the same as Example 1 by coupling 2-methyl-4-(2-(R)-methyl-[1,3′]bipyrrolidinyl-1′-yl)-phenylamine with 4-fluorobenzoyl chloride. LCMS: RT=1.57 minutes, MS: 382 (M+H).

Sources & evidence

ORD record
ord-989525c4b6e34e5b8aea93f75193f4e3
Source dataset
uspto-grants-2013_12
Patent number
US08618159B2

Reaction notes

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