5-Fluoro-2-methylbenzoyl chloride → HCID 67403883, compound

HRID 1916916Notes

Reaction equation

HRID 1916916 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:12][CH2:11][C@@H:10]([N:13]3[CH2:17][CH2:16][CH2:15][C@H:14]3[CH3:18])[CH2:9]2)[CH:5]=[CH:4][C:3]=1[NH2:19].[F:20][C:21]1[CH:22]=[CH:23][C:24]([CH3:30])=[C:25]([CH:29]=1)[C:26]([Cl:28])=[O:27]>>[ClH:28].[F:20][C:21]1[CH:22]=[CH:23][C:24]([CH3:30])=[C:25]([CH:29]=1)[C:26]([NH:19][C:3]1[CH:4]=[CH:5][C:6]([N:8]2[CH2:12][CH2:11][C@@H:10]([N:13]3[CH2:17][CH2:16][CH2:15][C@H:14]3[CH3:18])[CH2:9]2)=[CH:7][C:2]=1[CH3:1])=[O:27]

Participants

3

Reactant 2

HCID 27373835-Fluoro-2-methylbenzoyl chlorideHCID 594017862-methyl-4-(2-(R)-methyl-[1,3'(R)]bipyrrolidinyl-1'-yl)-phenylamine

Product 1

HCID 67403883HCID 67403883, compound

Procedure

The title compound was prepared in a manner substantially the same as Example 1 by coupling 2-methyl-4-(2-(R)-methyl-[1,3′(R)]bipyrrolidinyl-1′-yl)-phenylamine with 5-fluoro-2-methyl-benzoyl chloride (from Alfa Aesar).

Sources & evidence

ORD record
ord-422da481cc7e44fd8780610da11ef498
Source dataset
uspto-grants-2013_12
Patent number
US08618159B2

Reaction notes

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