3-Fluorobenzoic Acid → 3-Fluoro-N-[2-methyl-4-(2-(S)-methyl-[1,3'(S)]bipyrrolidinyl-1'-yl)-phenyl]-benzamide

HRID 1916917Notes

Reaction equation

HRID 1916917 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:12][CH2:11][C@H:10]([N:13]3[CH2:17][CH2:16][CH2:15][C@@H:14]3[CH3:18])[CH2:9]2)[CH:5]=[CH:4][C:3]=1[NH2:19].[F:20][C:21]1[CH:22]=[C:23]([CH:27]=[CH:28][CH:29]=1)[C:24](O)=[O:25]>>[F:20][C:21]1[CH:22]=[C:23]([CH:27]=[CH:28][CH:29]=1)[C:24]([NH:19][C:3]1[CH:4]=[CH:5][C:6]([N:8]2[CH2:12][CH2:11][C@H:10]([N:13]3[CH2:17][CH2:16][CH2:15][C@@H:14]3[CH3:18])[CH2:9]2)=[CH:7][C:2]=1[CH3:1])=[O:25]

Participants

3

Reactant 2

HCID 99683-Fluorobenzoic AcidHCID 594017642-methyl-4-(2-(S)-methyl-[1,3'(S)]bipyrrolidinyl-1'-yl)-phenylamine

Product 1

HCID 594018613-Fluoro-N-[2-methyl-4-(2-(S)-methyl-[1,3'(S)]bipyrrolidinyl-1'-yl)-phenyl]-benzamide

Procedure

The title compound was prepared in a manner substantially the same as Example 1 by coupling 2-methyl-4-(2-(S)-methyl-[1,3′(S)]bipyrrolidinyl-1′-yl)-phenylamine with 3-fluoro-benzoic acid. LCMS: RT=2.26 minutes, MS: 382 (M+H).

Sources & evidence

ORD record
ord-59d30df0e03840d382322feac9cd1154
Source dataset
uspto-grants-2013_12
Patent number
US08618159B2

Reaction notes

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