2,5-Dioxo-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-8-carboxylic acid → HCID 25271461, compound

HRID 1916920Notes

Reaction equation

HRID 1916920 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:12][CH2:11][CH:10]([N:13]3[CH2:17][CH2:16][CH2:15][CH:14]3[CH3:18])[CH2:9]2)[CH:5]=[CH:4][C:3]=1[NH2:19].[O:20]=[C:21]1[NH:27][C:26]2[CH:28]=[C:29]([C:32](O)=[O:33])[CH:30]=[CH:31][C:25]=2[C:24](=[O:35])[NH:23][CH2:22]1>>[CH3:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:12][CH2:11][CH:10]([N:13]3[CH2:17][CH2:16][CH2:15][CH:14]3[CH3:18])[CH2:9]2)[CH:5]=[CH:4][C:3]=1[NH:19][C:32]([C:29]1[CH:30]=[CH:31][C:25]2[C:24](=[O:35])[NH:23][CH2:22][C:21](=[O:20])[NH:27][C:26]=2[CH:28]=1)=[O:33]

Participants

3

Reactant 2

HCID 27573732,5-Dioxo-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-8-carboxylic acidHCID 594018302-Methyl-4-(2-methyl-[1,3']bipyrrolidinyl-1'-yl)-phenylamine

Product 1

HCID 25271461HCID 25271461, compound

Procedure

The title compound was prepared in a manner substantially the same as example 1 by coupling 2-methyl-4-(2-methyl-[1,3′]bipyrrolidinyl-1′-yl)-phenylamine with 2,5-Dioxo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-8-carboxylic acid. MS: 462.3 (M+H).

Sources & evidence

ORD record
ord-93917be40f614774bde384554680c300
Source dataset
uspto-grants-2013_12
Patent number
US08618159B2

Reaction notes

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