6-Methoxy-1-benzofuran-2-carboxylic acid → 6-Methoxy-benzofuran-2-carboxylic acid [2-methyl-4-(2-methyl-[1,3']bipyrrolidinyl-1'-yl)-phenyl]-amide

HRID 1916926Notes

Reaction equation

HRID 1916926 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:12][CH2:11][CH:10]([N:13]3[CH2:17][CH2:16][CH2:15][CH:14]3[CH3:18])[CH2:9]2)[CH:5]=[CH:4][C:3]=1[NH2:19].[CH3:20][O:21][C:22]1[CH:33]=[CH:32][C:25]2[CH:26]=[C:27]([C:29](O)=[O:30])[O:28][C:24]=2[CH:23]=1>>[CH3:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:12][CH2:11][CH:10]([N:13]3[CH2:17][CH2:16][CH2:15][CH:14]3[CH3:18])[CH2:9]2)[CH:5]=[CH:4][C:3]=1[NH:19][C:29]([C:27]1[O:28][C:24]2[CH:23]=[C:22]([O:21][CH3:20])[CH:33]=[CH:32][C:25]=2[CH:26]=1)=[O:30]

Participants

3

Reactant 2

HCID 9188636-Methoxy-1-benzofuran-2-carboxylic acidHCID 594018302-Methyl-4-(2-methyl-[1,3']bipyrrolidinyl-1'-yl)-phenylamine

Product 1

HCID 252662376-Methoxy-benzofuran-2-carboxylic acid [2-methyl-4-(2-methyl-[1,3']bipyrrolidinyl-1'-yl)-phenyl]-amide

Procedure

The title compound was prepared in a manner substantially the same as example 1 by coupling 2-methyl-4-(2-methyl-[1,3′]bipyrrolidinyl-1′-yl)-phenylamine with 6-methoxy-benzofuran-2-carboxylic acid. MS: 434.2 (M+H).

Sources & evidence

ORD record
ord-9ce12a31fc254c5092436a24beebc3d4
Source dataset
uspto-grants-2013_12
Patent number
US08618159B2

Reaction notes

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