5-methyl-2-phenyl-2H-1,2,3-triazole-4-carboxylic acid → 5-Methyl-2-phenyl-2H-[1,2,3]triazole-4-carboxylic acid [2-methyl-4-(2-methyl-[1,3']bipyrrolidinyl-1'-yl)-phenyl]-amide

HRID 1916952Notes

Reaction equation

HRID 1916952 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:12][CH2:11][CH:10]([N:13]3[CH2:17][CH2:16][CH2:15][CH:14]3[CH3:18])[CH2:9]2)[CH:5]=[CH:4][C:3]=1[NH2:19].[CH3:20][C:21]1[C:22]([C:32](O)=[O:33])=[N:23][N:24]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[N:25]=1>>[CH3:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:12][CH2:11][CH:10]([N:13]3[CH2:17][CH2:16][CH2:15][CH:14]3[CH3:18])[CH2:9]2)[CH:5]=[CH:4][C:3]=1[NH:19][C:32]([C:22]1[C:21]([CH3:20])=[N:25][N:24]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[N:23]=1)=[O:33]

Participants

3

Reactant 2

HCID 5199365-methyl-2-phenyl-2H-1,2,3-triazole-4-carboxylic acidHCID 594018302-Methyl-4-(2-methyl-[1,3']bipyrrolidinyl-1'-yl)-phenylamine

Product 1

HCID 594018195-Methyl-2-phenyl-2H-[1,2,3]triazole-4-carboxylic acid [2-methyl-4-(2-methyl-[1,3']bipyrrolidinyl-1'-yl)-phenyl]-amide

Procedure

The title compound was prepared in a manner substantially the same as example 1 by coupling 2-methyl-4-(2-methyl-[1,3′]bipyrrolidinyl-1′-yl)-phenylamine with 5-methyl-2-phenyl-2H-[1,2,3]triazole-4-carboxylic acid. MS: 445.4 (M+H).

Sources & evidence

ORD record
ord-e328fb5e9b3444e6831ff2180fc07d8c
Source dataset
uspto-grants-2013_12
Patent number
US08618159B2

Reaction notes

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