2,3-Dihydrobenzo(b)furan-5-carboxylic acid → 2,3-Dihydro-benzofuran-5-carboxylic acid [2-methyl-4-(2-methyl-[1,3']bipyrrolidinyl-1'-yl)-phenyl]-amide

HRID 1916953Notes

Reaction equation

HRID 1916953 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:12][CH2:11][CH:10]([N:13]3[CH2:17][CH2:16][CH2:15][CH:14]3[CH3:18])[CH2:9]2)[CH:5]=[CH:4][C:3]=1[NH2:19].[O:20]1[C:24]2[CH:25]=[CH:26][C:27]([C:29](O)=[O:30])=[CH:28][C:23]=2[CH2:22][CH2:21]1>>[CH3:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:12][CH2:11][CH:10]([N:13]3[CH2:17][CH2:16][CH2:15][CH:14]3[CH3:18])[CH2:9]2)[CH:5]=[CH:4][C:3]=1[NH:19][C:29]([C:27]1[CH:26]=[CH:25][C:24]2[O:20][CH2:21][CH2:22][C:23]=2[CH:28]=1)=[O:30]

Participants

3

Reactant 2

HCID 6765832,3-Dihydrobenzo(b)furan-5-carboxylic acidHCID 594018302-Methyl-4-(2-methyl-[1,3']bipyrrolidinyl-1'-yl)-phenylamine

Product 1

HCID 594018362,3-Dihydro-benzofuran-5-carboxylic acid [2-methyl-4-(2-methyl-[1,3']bipyrrolidinyl-1'-yl)-phenyl]-amide

Procedure

The title compound was prepared in a manner substantially the same as example 1 by coupling 2-methyl-4-(2-methyl-[1,3′]bipyrrolidinyl-1′-yl)-phenylamine with 2,3-dihydro-benzofuran-5-carboxylic acid. MS: 406.4 (M+H).

Sources & evidence

ORD record
ord-11d94317b82a4c9eb1a6fcdfaf069f20
Source dataset
uspto-grants-2013_12
Patent number
US08618159B2

Reaction notes

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