6-Methoxy-1H-indazole-3-carboxylic acid → 6-Methoxy-1H-indazole-3-carboxylic acid [2-methyl-4-(2-methyl-[1,3']bipyrrolidinyl-1'-yl)-phenyl]-amide
Reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:12][CH2:11][CH:10]([N:13]3[CH2:17][CH2:16][CH2:15][CH:14]3[CH3:18])[CH2:9]2)[CH:5]=[CH:4][C:3]=1[NH2:19].[CH3:20][O:21][C:22]1[CH:30]=[C:29]2[C:25]([C:26]([C:31](O)=[O:32])=[N:27][NH:28]2)=[CH:24][CH:23]=1>>[CH3:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:12][CH2:11][CH:10]([N:13]3[CH2:17][CH2:16][CH2:15][CH:14]3[CH3:18])[CH2:9]2)[CH:5]=[CH:4][C:3]=1[NH:19][C:31]([C:26]1[C:25]2[C:29](=[CH:30][C:22]([O:21][CH3:20])=[CH:23][CH:24]=2)[NH:28][N:27]=1)=[O:32]Participants
3
Procedure
The title compound was prepared in a manner substantially the same as example 1 by coupling 2-methyl-4-(2-methyl-[1,3′]bipyrrolidinyl-1′-yl)-phenylamine with 6-methoxy-1H-indazole-3-carboxylic acid. MS: 434.3 (M+H).
Sources & evidence
- ORD record
- ord-65ae1f810a1d4750a5a14e41684bb640
- Source dataset
- uspto-grants-2013_12
- Patent number
- US08618159B2
Reaction notes
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