4-(1-Propoxyethyl)benzoic acid → N-[2-Methyl-4-(2-methyl-[1,3']bipyrrolidinyl-1'-yl)-phenyl]-4-(1-propoxy-ethyl)-benzamide

HRID 1916961Notes

Reaction equation

HRID 1916961 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:12][CH2:11][CH:10]([N:13]3[CH2:17][CH2:16][CH2:15][CH:14]3[CH3:18])[CH2:9]2)[CH:5]=[CH:4][C:3]=1[NH2:19].[CH2:20]([O:23][CH:24]([C:26]1[CH:34]=[CH:33][C:29]([C:30](O)=[O:31])=[CH:28][CH:27]=1)[CH3:25])[CH2:21][CH3:22]>>[CH3:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:12][CH2:11][CH:10]([N:13]3[CH2:17][CH2:16][CH2:15][CH:14]3[CH3:18])[CH2:9]2)[CH:5]=[CH:4][C:3]=1[NH:19][C:30](=[O:31])[C:29]1[CH:33]=[CH:34][C:26]([CH:24]([O:23][CH2:20][CH2:21][CH3:22])[CH3:25])=[CH:27][CH:28]=1

Participants

3

Reactant 2

HCID 144734334-(1-Propoxyethyl)benzoic acidHCID 594018302-Methyl-4-(2-methyl-[1,3']bipyrrolidinyl-1'-yl)-phenylamine

Product 1

HCID 59401901N-[2-Methyl-4-(2-methyl-[1,3']bipyrrolidinyl-1'-yl)-phenyl]-4-(1-propoxy-ethyl)-benzamide

Procedure

The title compound was prepared in a manner substantially the same as example 1 by coupling 2-methyl-4-(2-methyl-[1,3′]bipyrrolidinyl-1′-yl)-phenylamine with 4-(1-propoxy-ethyl)-benzoic acid. MS: 463.3 (M+H).

Sources & evidence

ORD record
ord-c7c153e1e6dd4bc7a4cf57b2b4f9a6e2
Source dataset
uspto-grants-2013_12
Patent number
US08618159B2

Reaction notes

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