4-Nitrobenzylamine hydrochloride → HCID 44595607, compound

HRID 1916994Notes

Reaction equation

HRID 1916994 reaction equation
[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([C:6]([C:8]2[CH2:13][CH2:12][CH2:11][CH2:10][C:9]=2[C:14]([OH:16])=O)=[O:7])=[CH:4][CH:3]=1.Cl.[N+:20]([C:23]1[CH:30]=[CH:29][C:26]([CH2:27][NH2:28])=[CH:25][CH:24]=1)([O-:22])=[O:21]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]2([OH:7])[C:8]3[CH2:13][CH2:12][CH2:11][CH2:10][C:9]=3[C:14](=[O:16])[N:28]2[CH2:27][C:26]2[CH:25]=[CH:24][C:23]([N+:20]([O-:22])=[O:21])=[CH:30][CH:29]=2)=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 112524674-Nitrobenzylamine hydrochlorideHCID 58433799HCID 58433799, compound

Product 1

HCID 44595607HCID 44595607, compoundYield 44.4%

Procedure

The named compound was synthesised from, 2-(4-chlorobenzoyl)cyclohex-1-enecarboxylic acid (1.00 g, 3.78 mmol) and 4-nitrobenzylamine hydrochloride (0.78 g, 4.16 mmol) using General Procedure B, purified by chromatography (Biotage SP4; 30% EtOAc/petrol) and obtained as a yellow solid (0.67 g, 44%).

Workup

  1. custompurified by chromatography (Biotage SP4; 30% EtOAc/petrol)

Sources & evidence

ORD record
ord-de42cd25400e4502875f2c7d56ff9afa
Source dataset
uspto-grants-2013_12
Patent number
US08618158B2

Reaction notes

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