HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1917063Generated: November 1, 2026
Formaldehyde → Methyl 7-methoxy-2,3-dihydrobenzo[f][1,4]thiazepine-4(5H)-carboxylate
https://huagongshe.com/reaction/1917063
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | Methyl 2-(4-methoxyphenylthio)ethylcarbamate | HCID 57864658 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | Methyl 7-methoxy-2,3-dihydrobenzo[f][1,4]thiazepine-4(5H)-carboxylate | HCID 57864656 | 208.5% |
Reaction Steps
A mixture of compound 7 (95 mg), paraformaldehyde (95 mg, excess), p-toluenesulfonic acid (30 mg) in benzene (4 mL) was stirred at 60° C. overnight. Analysis by TLC showed a new spot and the complete disappearance of the starting material. Filtration, followed by concentration and chromatography on SiO2 gave 92 mg of pure product 8. Yield: 95%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08618282B2 |
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| Source dataset | uspto-grants-2013_12 |
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| ORD ID | ord-54c61a7275e34b959877eacc7f458d2c |
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| Source note | uspto-grants-2013_12 |
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