Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | HCID 57864663 | HCID 57864663 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 57864673 | HCID 57864673 | 70% |
Reaction Steps
A mixture of compound 12 (100 mg), paraformaldehyde (100 mg), p-toluenesulfonic acid (60 mg) in toluene (10 mL) was stirred at 80° C. overnight. Filtration, followed by washing with sat. NaHCO3 solution gave crude product 13 in an estimated yield of ˜70% by TLC and NMR.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08618282B2 |
|---|
| Source dataset | uspto-grants-2013_12 |
|---|
| ORD ID | ord-bef06670a9a14c22bd05cc7b0ec226e6 |
|---|
| Source note | uspto-grants-2013_12 |
|---|
