HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1917071Generated: November 3, 2026
Formaldehyde → (7-Methoxy-2,3-dihydrobenzo[f][1,4]thiazepin-4(5H)-yl)(morpholino)methanone
https://huagongshe.com/reaction/1917071
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | N-(2-(4-Methoxyphenylthio)ethyl)morpholine-4-carboxamide | HCID 17744820 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | (7-Methoxy-2,3-dihydrobenzo[f][1,4]thiazepin-4(5H)-yl)(morpholino)methanone | HCID 57864674 | 50% |
Reaction Steps
A mixture of compound 16 (100 mg), paraformaldehyde (110 mg), p-toluenesulfonic acid (60 mg) in benzene (5 mL) was stirred at 70-75° C. for 14 h. The reaction solution was filtrated, washed with sat. NaHCO3 and concentrated to give crude title product 17 in an estimated yield of ˜50% by TLC and NMR. Chromatography on SiO2 (CH2Cl2/EtOAc 10:1) provided pure sample for confirmation of the structure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08618282B2 |
|---|
| Source dataset | uspto-grants-2013_12 |
|---|
| ORD ID | ord-8f95687f9eef40c387228e9cc72c858f |
|---|
| Source note | uspto-grants-2013_12 |
|---|
