HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1917073Generated: October 26, 2026
Formaldehyde → Benzyl 4-(7-methoxy-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepine-4-carbonyl)piperazine-1-carboxylate
https://huagongshe.com/reaction/1917073
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | Benzyl 4-(2-(4-methoxyphenylthio)ethylcarbamoyl)piperazine-1-carboxylate | HCID 68626717 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | Benzyl 4-(7-methoxy-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepine-4-carbonyl)piperazine-1-carboxylate | HCID 68639517 | — |
Reaction Steps
A mixture of compound 18 (30 mg), paraformaldehyde (100 mg), p-toluenesulfonic acid (30 mg) in benzene (5 mL) was stirred at 70-75° C. for 2 days. The reaction mixture was filtered, washed with sat. NaHCO3 and concentrated to give crude product 19, which was purified by chromatography on SiO2 (CH2Cl2/EtOAc 10:1). Yield: 21 mg, 69%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08618282B2 |
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| Source dataset | uspto-grants-2013_12 |
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| ORD ID | ord-cf7ef04c2d2c430f8b23f2c0fcb441b2 |
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| Source note | uspto-grants-2013_12 |
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