Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | HCID 57864655 | HCID 57864655 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 57864661 | HCID 57864661 | — |
Reaction Steps
A mixture of compound 25(120 mg), paraformaldehyde (120 mg, excess), p-toluenesulfonic acid (40 mg) in toluene (10 mL) was stirred at 70° C. for 24 h. The reaction mixture was filtered and washed with sat. NaHCO3 (2×5 mL). Removal of the solvent gave product 26 as a pure product by TLC and NMR. Yield: 110 mg, 89%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08618282B2 |
|---|
| Source dataset | uspto-grants-2013_12 |
|---|
| ORD ID | ord-6582cdf73b954b4eb93068a17cb88e31 |
|---|
| Source note | uspto-grants-2013_12 |
|---|
