HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1917091Generated: November 3, 2026
Piperazine → 2,4-dimethyl-6-(piperazin-1-yl)-1,2,4-triazine-3,5(2H,4H)-dione
https://huagongshe.com/reaction/1917091
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 6-Bromo-2,4-dimethyl-2,3,4,5-tetrahydro-1,2,4-triazine-3,5-dione | HCID 260563 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2,4-dimethyl-6-(piperazin-1-yl)-1,2,4-triazine-3,5(2H,4H)-dione | HCID 33781065 | 79.6% |
Reaction Steps
4.75 g (55.15 mmol) of piperazine are placed in the presence of 4.05 g (18.4 mmol) of intermediate 1b in toluene at room temperature for 30 min. 2.8 mL (20.1 mmol) of triethylamine are added and the mixture is heated for 18 h at 110° C. After concentration of the reaction medium, the obtained residue is taken up with dichloromethane and washed with water. After drying on MgSO4, the organic phase is dry concentrated. The obtained residue is purified by flash chromatography (CH2Cl2-MeOH: 60-40). 3.3 g of intermediate 12a is obtained as a white powder (yield: 79%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08618287B2 |
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| Source dataset | uspto-grants-2013_12 |
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| ORD ID | ord-7c7773de857c4d83bca4048051377588 |
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| Source note | uspto-grants-2013_12 |
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