Dimethylformamide → HCID 58269808, compound

Participants

Reaction Conditions

Reaction Steps

9.6 g (33.53 mmol) of 5-(4-benzyl-piperazin-1-yl)-1H-pyrimidine-2,4-dione are placed at 0° C. in 10 mL of dimethylformamide. 2.95 g (73.56 mmol) of sodium hydride (at 60% in paraffin) are added portion wise. The mixture is stirred for 40 min at 0° C. 5 mL (80.5 mmol) of methyl iodide are added, the medium is stirred at room temperature for 7 h. After concentration of the reaction medium, the obtained residue is taken up with AcOEt and washed with water. After drying on MgSO4, the organic phase is concentrated. The obtained residue is triturated with ether, and then a precipitate is isolated by filtration. 4 g of intermediate 13a are obtained as a beige powder (yield: 38%).

Provenance & Evidence