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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1917096Generated: November 2, 2026

1-(2-Trifluoromethylbenzoyl)piperazine hydrochloride → 1-Butanol

https://huagongshe.com/reaction/1917096

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(2-Trifluoromethylbenzoyl)piperazine hydrochlorideHCID 16733783—
Reactant6-Bromo-4-methyl-2-(4,4,4-trifluoro-butyl)-2H-[1,2,4]triazine-3,5-dioneHCID 59298833—
Product1-ButanolHCID 26319%
Product4-methyl-2-(4,4,4-trifluoro-butyl)-6-[4-(2-trifluoromethyl-benzoyl)-piperazin-1-yl]-2H-[1,2,4]triazine-3,5-dioneHCID 44621495—

Reaction Steps

The compound 3 (oil) is prepared from the triazine 4a and from the intermediate 6a according to the synthesis method 1 in n-butanol (yield: 19%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08618287B2
Source datasetuspto-grants-2013_12
ORD IDord-4a450a8d2ac64d7dbd8014e6ff0b11c8
Source noteuspto-grants-2013_12