4-Benzylpiperidine → 1-Butanol

HRID 1917103Notes

Reaction equation

HRID 1917103 reaction equation
Br[C:2]1[C:3](=[O:11])[N:4]([CH3:10])[C:5](=[O:9])[N:6]([CH3:8])[N:7]=1.[CH2:12]([CH:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[CH2:3]([OH:11])[CH2:2][CH2:12][CH3:13].[CH2:12]([CH:19]1[CH2:24][CH2:23][N:22]([C:2]2[C:3](=[O:11])[N:4]([CH3:10])[C:5](=[O:9])[N:6]([CH3:8])[N:7]=2)[CH2:21][CH2:20]1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 317384-BenzylpiperidineHCID 2605636-Bromo-2,4-dimethyl-2,3,4,5-tetrahydro-1,2,4-triazine-3,5-dione

Product 2

HCID 2631-ButanolYield 93%HCID 58269802HCID 58269802, compound

Procedure

The compound 10 (oil) is prepared from the triazine 1b and from 4-benzyl-piperidine according to the synthesis method 1 in n-butanol (yield: 93%).

Sources & evidence

ORD record
ord-ed31c398927047cebfdbab6ec04b0542
Source dataset
uspto-grants-2013_12
Patent number
US08618287B2

Reaction notes

Loading…