4-(2-Chlorophenoxy)piperidine → 1-Butanol

HRID 1917105Notes

Reaction equation

HRID 1917105 reaction equation
Br[C:2]1[C:3](=[O:17])[N:4]([CH3:16])[C:5](=[O:15])[N:6]([CH2:8][CH2:9][CH2:10][C:11]([F:14])([F:13])[F:12])[N:7]=1.[Cl:18][C:19]1[CH:31]=[CH:30][CH:29]=[CH:28][C:20]=1[O:21][CH:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1>>[Cl:18][C:19]1[CH:31]=[CH:30][CH:29]=[CH:28][C:20]=1[O:21][CH:22]1[CH2:27][CH2:26][N:25]([C:2]2[C:3](=[O:17])[N:4]([CH3:16])[C:5](=[O:15])[N:6]([CH2:8][CH2:9][CH2:10][C:11]([F:14])([F:13])[F:12])[N:7]=2)[CH2:24][CH2:23]1.[CH2:20]([OH:21])[CH2:19][CH2:31][CH3:30]

Participants

4

Reactant 2

HCID 38646564-(2-Chlorophenoxy)piperidineHCID 59298833HCID 59298833, compound

Product 2

HCID 2631-ButanolYield 77%HCID 44621506HCID 44621506, compound

Procedure

The compound 25 (oil) is prepared from the triazine 4a and the intermediate 8a according to the synthesis method 1 in n-butanol (yield: 77%).

Sources & evidence

ORD record
ord-5b45be8751004365b2d3eddb2babdbaa
Source dataset
uspto-grants-2013_12
Patent number
US08618287B2

Reaction notes

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