HRID1917112

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID605680

4-Fluoro-2-(trifluoromethyl)benzoyl chloride

C8H3ClF4O

HCID33781065

未命名化合物

PRODUCTS

生成物

结构：Cn1nc(N2CCN(C(=O)c3ccc(F)cc3C(F)(F)F)CC2)c(=O)n(C)c1=O

HCID58269757

未命名化合物

结构：Cn1nc(N2CCN(C(=O)c3cc(C(F)(F)F)ccc3C(F)(F)F)CC2)c(=O)n(C)c1=O

HCID58269815

未命名化合物

收率 61%

PROCEDURE

实验过程

The compound 41 (solid) is prepared from 4-fluoro-2-trifluoromethyl-benzoyl chloride and from the intermediate 12a according to the synthesis method 2 under the operating conditions described for Example 40 (yield: 61%).

WORKUP

后处理

customaccording to the synthesis method 2 under the operating conditions

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-7881d5dfd5874c6e8d91a4346b2156be
来源数据集: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08618287B2
来源说明: uspto-grants-2013_12

反应 SMILES

[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[C:4]([C:11]([F:14])([F:13])[F:12])[CH:3]=1.[CH3:15][N:16]1[C:21](=[O:22])[N:20]([CH3:23])[C:19](=[O:24])[C:18]([N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)=[N:17]1>>[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:28]2[CH2:27][CH2:26][N:25]([C:18]3[C:19](=[O:24])[N:20]([CH3:23])[C:21](=[O:22])[N:16]([CH3:15])[N:17]=3)[CH2:30][CH2:29]2)=[O:7])=[C:4]([C:11]([F:14])([F:13])[F:12])[CH:3]=1.[F:12][C:11]([F:14])([F:13])[C:4]1[CH:3]=[CH:2][C:10]([C:11]([F:14])([F:13])[F:12])=[CH:9][C:5]=1[C:6]([N:28]1[CH2:27][CH2:26][N:25]([C:18]2[C:19](=[O:24])[N:20]([CH3:23])[C:21](=[O:22])[N:16]([CH3:15])[N:17]=2)[CH2:30][CH2:29]1)=[O:7]