HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Trifluoromethyl)benzoyl chloride → 6-[4-(2,5-Bis-trifluoromethyl-benzoyl)-piperazin-1-yl]-2,4-dimethyl-2H-[1,2,4]triazine-3,5-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Trifluoromethyl)benzoyl chloride | HCID 67561 | — |
| Reactant | 2,4-dimethyl-6-(3-oxo-piperazin-1-yl)-2H-[1,2,4]triazine-3,5-dione | HCID 16352503 | — |
| Product | 2,4-dimethyl-6-[3-oxo-4-(2-trifluoromethyl-benzoyl)-piperazin-1-yl]-2H-[1,2,4]triazine-3,5-dione | HCID 58269766 | — |
| Product | 6-[4-(2,5-Bis-trifluoromethyl-benzoyl)-piperazin-1-yl]-2,4-dimethyl-2H-[1,2,4]triazine-3,5-dione | HCID 58269815 | 77% |
Reaction Steps
The compound 53 (solid) is prepared from 2-trifluoromethyl-benzoyl chloride and from the intermediate 12b according to the synthesis method 2 under the operating conditions described for Example 40 (yield: 77%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08618287B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-ac03d22165ba44bbb08a8d2fbb7ec138 |
| Source note | uspto-grants-2013_12 |