HCID 67490883, compound → HCID 58944935, compound

Participants

Reaction Steps

A 10% palladium-carbon catalyst (about 50% wet, 115 mg) was added to a solution of (+)-(1R*,5S*)-3-benzyloxycarbonyl-1-(tert-butoxycarbonylamino)-3-azabicyclo[3.3.0]octane (575 mg, 1.595 mmol) in methanol (20 mL), and the mixture was stirred in a hydrogen atmosphere at room temperature for two hours. The catalyst was removed by filtration, and then the solvent was evaporated under reduced pressure to give crude 1-(tert-butoxycarbonylamino)-3-azabicyclo[3.3.0]octane (388 mg) as a colorless transparent gummy solid.

Provenance & Evidence