Benzyl chloroformate → HCID 67490919, compound

Participants

Reaction Conditions

Reaction Steps

{(1S,5S)-6,6-Difluoro-3-[(1R)-1-phenylethyl]-3-azabicyclo[3,3,0]octan-1-yl}carboxylic acid tert-butyl ester (370.0 mg, 1.05 mmol) was dissolved in dichloromethane (3 mL). Benzyloxycarbonyl chloride (898 mg, 5.26 mmol) was added, and the mixture was stirred at 40° C. for 17 hours. The reaction solution was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (20% ethyl acetate/hexane) to give 338 mg of the title compound as a colorless oil.

Provenance & Evidence