Hexane → HCID 67491040, compound

Participants

Reaction Steps

The racemate (1R*,6S*)-8-benzyloxycarbonyl-1-tert-butoxycarbonylamino-8-azabicyclo[4.3.0]nonane (6.65 g, 17.8 mmol) was optically resolved by an optically active column (CHIRALPAK AD, 20 mm diameter×250 mm, hexane:isopropyl alcohol=95:5, flow rate=20 ml/min) to give optically active 8-benzyloxycarbonyl-1-tert-butoxycarbonylamino-8-azabicyclo[4.3.0]nonane (optical isomer A) (427 mg, 1.14 mmol, retention time=14.2 min) and its optically active enantiomer 8-benzyloxycarbonyl-1-tert-butoxycarbonylamino-8-azabicyclo[4.3.0]nonane (optical isomer B) (415 mg, 1.11 mmol, retention time=19.4 min).

Provenance & Evidence