HCID 67490967, compound → HCID 67491021, compound

Participants

Reaction Steps

(1S,5R)-3-Benzyloxycarbonyl-1-(tert-butoxycarbonylamino)-6-fluoromethyl-3-azabicyclo[3.2.0]heptane (derived from isomer B) (305 mg, 806 μmol) was dissolved in tetrahydrofuran (6 mL). 20% palladium hydroxide-carbon (50% wet) (100 mg) was added, and the mixture was stirred in a hydrogen atmosphere for one hour. The catalyst was removed by filtration, and then the filtrate was concentrated under reduced pressure. A 1 M sodium hydroxide solution was added to the residue under ice-cooling, followed by extraction with chloroform. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 196 mg of the title compound as a colorless syrup.

Provenance & Evidence