Water → HCID 86664662, compound

Participants

Reaction Steps

To a suspension of 7-[6-amino-8-azatricyclo[4.3.0.01,3]nonan-8-yl]-6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (2.24 g, 4.82 mmol) in ethanol (48.2 ml) was added methanesulfonic acid (0.316 ml, 4.87 mmol) and the mixture was stirred at room temperature for 15 hours. To this reaction solution was added water (5 ml) and the mixture was concentrated under reduced pressure. To this residue was added 2-propanol (20 ml) and the mixture was stirred at room temperature for 15 hours. The precipitated solids were collected by filtration. The solids were washed with an excess amount of 2-propanol to afford the title compound 2.41 g (95%) as pale yellow solid.

Provenance & Evidence