HCID 67491079, compound → HCID 67490928, compound

Participants

Reaction Conditions

Reaction Steps

[(3aS)-5-[(R)-1-Phenylethyl]tetrahydrofuro[3,4-c]pyrrol-3a-yl]carbamic acid tert-butyl ester (355 mg, 1.06 mmol) was dissolved in dioxane (10 ml) and 20% palladium hydroxide catalyst (20 wt. % Pd on carbon, wet; cat.) was added. The mixture was vigorously stirred under a hydrogen atmosphere at 40° C. for 24 h. After removing the catalyst by filtration, the filtrate was concentrated under reduced pressure. The residue was taken up in dichloromethane, and washed with 1N aq. NaOH and brine. The organic layer was dried over anhydrous sodium sulfate and the solvent removed in vacuo to give the crude title compound (243 mg) as a colorless syrup.

Provenance & Evidence