HCID 67491058, compound → HCID 131731119, compound

Participants

Reaction Steps

An [(S)-5-[(R)-1-Phenylethyl]tetrahydro-2-oxa-5-azacyclopropa[c]pentalen-3a-yl]carbamic acid tert-butyl ester (480 mg, 1.39 mmol) was dissolved in dioxane (10 ml) and 20% palladium hydroxide catalyst (20 wt. % Pd on carbon, wet; cat.) was added. The mixture was vigorously stirred under a hydrogen atmosphere at room temperature for 3 days. After removing the catalyst by filtration, the filtrate was concentrated under reduced pressure. The residue was taken up in dichloromethane, and washed with 1N aq. NaOH and brine. The organic layer was dried over anhydrous sodium sulfate and the solvent removed in vacuo to give the crude title compound as a white solid (280 mg).

Provenance & Evidence