HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 45257321, compound → HCID 178501472, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 45257321 | HCID 45257321 | — |
| Reactant | (S)-methyl 4-(1,3-dioxoisoindolin-2-yloxy)-2-methoxybutanoate | HCID 67065361 | — |
| Catalyst | Diacetyloxymercury | HCID 16683746 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 178501472 | HCID 178501472 | 12% |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
A mixture of (R)-2-amino-7-(2-bromo-4-fluorophenyl)-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidine-5(6H)-thione (311, 146 mg, 0.4 mmol), (S)-methyl 4-(aminooxy)-2-methoxybutanoate (46c, 260 mg, 1.6 mmol), Hg(OAc)2 (257 mg, 0.8 mmol) and toluene (2 mL) was heated at 100° C. for 2 h. Cooled to rt, filtered through celite and purified to afford (S)-methyl 4-((Z)—((R)-2-amino-7-(2-bromo-4-fluorophenyl)-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-ylidene)aminooxy)-2-methoxybutanoate (23 mg, 12%) as off white solid. MS (ES) [M+H] calculated for C20H24BrFN5O4, 496.09; found 496.20.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08618290B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-7474f1d6bc364744bb97f9b831d26830 |
| Source note | uspto-grants-2013_12 |