HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → (S)-2-(tert-butyldimethylsilyloxy)-4-hydroxybutanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 3-(tert-butyldimethylsilyloxy)dihydrofuran-2(3H)-one | HCID 5046241 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (S)-2-(tert-butyldimethylsilyloxy)-4-hydroxybutanamide | HCID 57999203 | — |
Reaction Steps
To a solution of 3-(tert-butyldimethylsilyloxy)dihydrofuran-2(3H)-one (11 g, 49 mmol) in methanol was added 7 N ammonia in methanol (20 mL, 140 mmol). The reaction was stirred in a sealed tube for 2 days. The solvent was removed in vacuo to yield (S)-2-(tert-butyldimethylsilyloxy)-4-hydroxybutanamide (4.85 g, 20.8 mmol) as a white solid. [M+H] calc'd for C10H23NO3Si, 234; found, 234.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08618290B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-67fdef132c814f3ba814d75be9d4cc93 |
| Source note | uspto-grants-2013_12 |