HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 58464112, compound → HCID 58464167, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 58464112 | HCID 58464112 | — |
| Catalyst | Palladium hydroxide | HCID 9942167 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 58464167 | HCID 58464167 | 92% |
Reaction Steps
(RS)-3-(tert-Butyl-diphenyl-silanyloxy)-4-dibenzylamino-2-methyl-butan-2-ol (Example 95, step 2) was hydrogenated in EtOH with Pd(OH)2 for 16 hours at 60° C. The desired (RS)-4-amino-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-butan-2-ol (4.2 g, 92% yield) was obtained as a colorless oil, MS: m/e=358.2 (M+H+) and used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08618296B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-d81a159633bc46689baff1a0c9e535a7 |
| Source note | uspto-grants-2013_12 |