Hydrochloric Acid → HCID 58505676, compound

Participants

Reaction Conditions

Reaction Steps

A solution of ethyl 3-{3-[(4-chlorophenyl)carbonyl]-1-(2,2-dimethylpropanoyl)-7-(pyridin-2-ylmethoxy)indolizin-2-yl}-2,2-dimethylpropanoate (98 mg, 0.17 mmol) in THF (1 mL), MeOH (1 mL), and 6M aqueous NaOH (0.75 mL) is heated at 50° C. for 3 h then cooled to 23° C. and acidified to pH=1 with concentrated aqueous HCl. The mixture is partitioned between CH2Cl2 and brine then the organics are collected and dried with MgSO4, filtered, and concentrated in vacuo to afford the title compound (80 mg, 86%).

Provenance & Evidence