Potassium Carbonate → HCID 58505816, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of ethyl 3-{1-[(4-chlorophenyl)carbonyl]-3-(2,2-dimethylpropanoyl)-6-hydroxyindolizin-2-yl}-2,2-dimethylpropanoate (85.0 mg, 0.176 mmol), 2-(chloromethyl)-1,3-benzothiazole-HCl (60.1 mg, 0.263 mmol), and potassium carbonate (97.1, 0.703 mmol) in DMF (3.0 mL) is stirred at 50° C. for 1 h. The mixture is cooled to 23° C. then filtered, concentrated in vacuo, and purified by flash chromatography (SiO2, hexanes to 1:1 hexanes:EtOAc) to yield ethyl 3-[6-(1,3-benzothiazol-2-ylmethoxy)-1-[(4-chlorophenyl)carbonyl]-3-(2,2-dimethylpropanoyl)indolizin-2-yl]-2,2-dimethylpropanoate (74 mg, 67%).

Provenance & Evidence