Acetic Acid → HCID 58505812, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of methyl N-{[1-(2,2-dimethylpropanoyl)-2-methyl-7-(propan-2-yl)indolizin-3-yl]carbonyl}-N-phenyl-beta-alaninate (60 mg, 0.13 mmol) in 1,4-dioxane (5 mL) and water (1 mL) is added 10M aqueous NaOH (50 μL). The mixture is stirred at 23° C. for 2 h then acidified with HOAc, diluted water (5 mL), extracted with CH2Cl2, dried with MgSO4, filtered, and concentrated in vacuo to afford the title compound (42 mg, 72%).

Provenance & Evidence