HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine, hydrochloride → HCID 58505613, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine, hydrochloride | HCID 10473 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 58505568 | HCID 58505568 | — |
| Product | HCID 58505613 | HCID 58505613 | 34.2% |
Reaction Steps
To a solution of 3-{3-[(4-chlorophenyl)carbonyl]-1-(2,2-dimethylpropanoyl)-7-(propan-2-yl)indolizin-2-yl}-2,2-dimethylpropanoic acid (100 mg, 0.207 mmol), O-(7-azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate (157.7 mg, 0.415 mmol), and dimethylamine-HCl (18.6 mg, 0.228 mmol) is added TEA (0.173 mL, 1.245 mmol). The reaction is stirred for 16 h then purified by HPLC to give the title compound (36 mg, 34%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08618300B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-2204c0b604034fb8bf7b1e71f998194a |
| Source note | uspto-grants-2013_12 |