Water → HCID 58505750, compound

Participants

Reaction Conditions

Reaction Steps

A solution of ethyl 3-{3-[(4-bromophenyl)carbamoyl]-1-(2,2-dimethylpropanoyl)-7-(propan-2-yl)indolizin-2-yl}-2,2-dimethylpropanoate (55 mg, 0.097 mmol), 2-(methoxy)pyridine-5-boronic acid (15 mg, 0.097 mmol) and tetrakis(triphenylphosphine)palladium (0) (5 mg, 0.007 mmol) in 1,4-dioxane (4 mL) is heated in the microwave at 120° C. for 20 minutes then 100° C. for 16 h. The mixture is cooled to 23° C., poured into water and extracted with EtOAc. The combined organics are dried with MgSO4, filtered, and concentrated in vacuo. Purification of the crude by flash chromatography (SiO2, hexanes to 50% EtOAc in hexanes) gives ethyl 3-[1-(2,2-dimethylpropanoyl)-3-{[4-(6-methoxypyridin-3-yl)phenyl]carbamoyl}-7-(propan-2-yl)indolizin-2-yl]-2,2-dimethylpropanoate (22 mg, 38%) that is dissolved in 1,4-dioxane (3 mL) and water (0.5 mL). To this mixture is added 10M aqueous NaOH (5 drops) and solution is stirred at 23° C. until reaction is complete. The mixture is acidified with HOAc and resulting solid is filtered, washed with water, collected, and dried to give the title compound (14 mg, 67%).

Provenance & Evidence