HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-6,7-difluoroquinazoline → 1-(5-Tert-butylisoxazol-3-yl)-3-(3-(6,7-difluoroquinazolin-4-yloxy)phenyl)urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-6,7-difluoroquinazoline | HCID 21088278 | — |
| Reactant | 1-(5-Tert-butylisoxazol-3-yl)-3-(3-hydroxyphenyl)urea | HCID 66876595 | — |
| Product | 1-(5-Tert-butylisoxazol-3-yl)-3-(3-(6,7-difluoroquinazolin-4-yloxy)phenyl)urea | HCID 44243177 | — |
Reaction Steps
To the intermediate 1-(5-tert-butylisoxazol-3-yl)-3-(3-hydroxyphenyl)urea from Example 1A (110 mg, 0.4 mmol) was added 4-chloro-6,7-difluoroquinazoline from the previous step (80 mg, 0.4 mmol) according to the procedure described in Example 1B Step 1, to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08618289B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-d5311a6a077a40eb85ad87fca2ff7439 |
| Source note | uspto-grants-2013_12 |