HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1917646Generated: October 31, 2026
5-Tert-butyl-3-isocyanato-1,2-oxazole → 1-(5-Tert-butylisoxazol-3-yl)-3-(4-fluoro-3-hydroxyphenyl)urea
https://huagongshe.com/reaction/1917646
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 5-Tert-butyl-3-isocyanato-1,2-oxazole | HCID 12918838 | — |
| Reactant | 5-Amino-2-fluorophenol | HCID 22641413 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 1-(5-Tert-butylisoxazol-3-yl)-3-(4-fluoro-3-hydroxyphenyl)urea | HCID 66876776 | — |
Reaction Steps
A mixture of 5-amino-2-fluorophenol (1.3 g, 10.2 mmol) and 5-tert-butyl-3-isocyanatoisoxazole (1.7 g, 10.2 mmol) in toluene (60 mL) was heated at 70° C. overnight. The solid was filtered and dried under vacuum to afford 1-(5-tert-butylisoxazol-3-yl)-3-(4-fluoro-3-hydroxyphenyl)urea as solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08618289B2 |
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| Source dataset | uspto-grants-2013_12 |
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| ORD ID | ord-68a309d3b3634d0194fac8fb0954a47f |
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| Source note | uspto-grants-2013_12 |
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