HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 2-Cyano-2-methylpropionate → 2,2-Dimethyl-3-oxopentanedinitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 2-Cyano-2-methylpropionate | HCID 344887 | — |
| Reactant | 4-Methyl-3-oxopentanenitrile | HCID 10129921 | — |
| Product | 2,2-Dimethyl-3-oxopentanedinitrile | HCID 86620165 | 48% |
Reaction Steps
Prepared from ethyl 2-cyano-2-methylpropanoate (3 g, 21.25 mmol) according to the method described for 4-methyl-3-oxopentanenitrile in Example 122A Step 1, to afford 2,2-dimethyl-3-oxopentanedinitrile as a yellow oil (1.40 g, 48%) which was used in the next step without further purification. 1H NMR (300 MHz, CDCl3) δ 3.98 (s, 2H), 1.60 (s, 6H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08618289B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-91af9540386149bdb049c3edd0eb2ccf |
| Source note | uspto-grants-2013_12 |