化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → 5-Cyclopentyl-1,2-oxazol-3-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 5-(Propan-2-yl)-1,2-oxazol-3-amine | HCID 13334663 | — |
| 反応物 | 2-(2-cyclopentyl-1,3-dioxolan-2-yl)-N'-hydroxyacetimidamide | HCID 86653515 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 5-Cyclopentyl-1,2-oxazol-3-amine | HCID 66201008 | 62% |
反応手順
According to the procedure described for 5-isopropylisoxazol-3-amine in Example 133A Step 4, 2-(2-cyclopentyl-1,3-dioxolan-2-yl)-N′-hydroxyacetimidamide (1.99 g, 93 mmol) was dissolved in ethanol (2 mL) and acidified with 37% aq. hydrochloric acid to give 5-cyclopentylisoxazol-3-amine (875 mg, 62%) as a white solid. 1H NMR (300 MHz, CDCl3) δ 5.52 (s, 1H), 3.86 (bs, 2H), 3.09-3.04 (m, 1H), 2.04 (d, 2H), 1.75-1.62 (m, 6H); LC-MS (ESI) m/z 153 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08618289B2 |
| 出典データセット | uspto-grants-2013_12 |
| ORD ID | ord-03d5060adcda41758bc549fb8565bd15 |
| 出典メモ | uspto-grants-2013_12 |