HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1917934Generated: November 1, 2026
Phenylhydrazine hydrochloride → 3-(1,3-difluoro-2-methylpropan-2-yl)-1-phenyl-1H-pyrazol-5-amine
https://huagongshe.com/reaction/1917934
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phenylhydrazine hydrochloride | HCID 60962 | — |
| Reactant | 5-Fluoro-4-(fluoromethyl)-4-methyl-3-oxopentanenitrile | HCID 86653518 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-(1,3-difluoro-2-methylpropan-2-yl)-1-phenyl-1H-pyrazol-5-amine | HCID 66876213 | 59.7% |
Reaction Steps
According to the procedure described in Example 161B Step 2, 5-fluoro-4-(fluoromethyl)-4-methyl-3-oxopentanenitrile (0.81 g, 5 mmol) and phenylhydrazine hydrochloride (0.868 g, 14 mmol) in EtOH were heated at 95° C. for 2 hours, to afford 3-(1,3-difluoro-2-methylpropan-2-yl)-1-phenyl-1H-pyrazol-5-amine as solid (0.75 g, 52%). LC-MS (ESI) m/z 252 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08618289B2 |
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| Source dataset | uspto-grants-2013_12 |
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| ORD ID | ord-2d3508529299457aa0e52cba282b9b69 |
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| Source note | uspto-grants-2013_12 |
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