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HRID1918107

反应详情

EQUATION

反应方程式

HRID 1918107 的结构方程式

REACTANTS

反应物

3
结构：CC(C)(C)C(=O)CC#N
HCID108871

Pentanenitrile, 4,4-dimethyl-3-oxo-

C7H11NO

结构：Cc1ccc(NN)c(C)c1.Cl
HCID16213059

(2,4-Dimethylphenyl)hydrazine--hydrogen chloride (1/1)

C8H13ClN2

结构：CC(F)(F)C(=O)CC#N
HCID86653534

未命名化合物

PRODUCTS

生成物

1
结构：COc1ccc(-n2nc(C(C)(F)F)cc2N)cc1
HCID66875898

未命名化合物

收率 11%

PROCEDURE

实验过程

Following the procedure for Example 282A Step 1, substituting p-methoxyphenylhydrazine for 2,4-dimethylphenylhydrazine hydrochloride and 4,4-difluoro-3-oxopentanenitrile was substituted for 4,4-Dimethyl-3-oxopentanenitrile. Concentration and purification using silica gel chromatography eluting with EtOAc/hexanes (5-40%) afforded 3-(1,1-difluoroethyl)-1-(4-methoxyphenyl)-1H-pyrazol-5-amine in 11% yield. LC-MS (ESI) m/z 254 (M+H)+.

WORKUP

后处理

  1. concentrationConcentration and purification
  2. washeluting with EtOAc/hexanes (5-40%)