Cesium carbonate → HCID 70312045, compound

Participants

Reaction Steps

The procedure described in Example 3 is followed. Starting from 0.3 g (0.98 mmol) of 5-bromo-2-(4-chlorophenyl)pyrazolo[1,5-a]pyridine, obtained according to the protocol described in Examples 1.3 or 2.3, 0.18 mg (1.18 mmol) of 2-(hydroxymethyl)phenylboronic acid, 0.975 g (2.99 mmol) of caesium carbonate, 0.085 g (0.10 mmol) of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) and 5 ml of a THF/water (9/1) mixture and after chromatographing on silica gel, elution being carried out with a mixture of cyclohexane and ethyl acetate (7/3), 0.303 g (92%) of the expected product is obtained in the form of a white powder.

Provenance & Evidence