Tetrahydrofuran → HCID 71224836, compound

Participants

Reaction Steps

The procedure described in stage 6.2 is followed. Starting from 0.15 g (0.45 mmol) of 3-[2-(4-chlorophenyl)pyrazolo[1,5-a]pyridin-5-yl]benzaldehyde, obtained according to the process described in 6.1, in solution in 8 ml of tetrahydrofuran, followed by addition of 1.80 ml (0.9 mmol) of a cyclopropylmagnesium bromide solution (0.5M in tetrahydrofuran) and after chromatographing on silica gel, elution being carried out with a mixture of cyclohexane and ethyl acetate (8/2), 0.1 g (59%) of the expected product is obtained in the form of a beige powder.

Provenance & Evidence