HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 4-(benzyloxycarbonylamino)-5-bromo-2-(5-methoxypyrazin-2-yl)thiophene-3-carboxylate → Methyl 4-(benzyloxycarbonylamino)-2-(5-methoxypyrazin-2-yl)thiophene-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 4-(benzyloxycarbonylamino)-5-bromo-2-(5-methoxypyrazin-2-yl)thiophene-3-carboxylate | HCID 58191419 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol ethyl acetate methylene chloride | HCID 22027680 | — |
| Product | Methyl 4-(benzyloxycarbonylamino)-2-(5-methoxypyrazin-2-yl)thiophene-3-carboxylate | HCID 58191520 | — |
Reaction Steps
10% Pd/C is added to methyl 4-(benzyloxycarbonylamino)-5-bromo-2-(5-methoxypyrazin-2-yl)thiophene-3-carboxylate (157) in ethanol:ethyl acetate:dichloromethane (2:1:1). The mixture is degassed and placed under H2 (1 atm) and stirred for 4 h. The mixture is filtered through a 0.45 μm syringe filter and concentrated under reduced pressure. Flash chromatography (ISCO system, silica, 0-50% ethyl acetate in hexane) provides 158.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08618307B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-6e0cc6a2945146218d36960dc266ca73 |
| Source note | uspto-grants-2013_12 |