HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 4-(benzyloxycarbonylamino)-5-bromo-2-p-tolylthiophene-3-carboxylate → Methyl 4-(benzyloxycarbonylamino)-2-p-tolylthiophene-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 4-(benzyloxycarbonylamino)-5-bromo-2-p-tolylthiophene-3-carboxylate | HCID 58191383 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol ethyl acetate methylene chloride | HCID 22027680 | — |
| Product | Methyl 4-(benzyloxycarbonylamino)-2-p-tolylthiophene-3-carboxylate | HCID 58191198 | — |
Reaction Steps
10% Pd/C is added to methyl 4-(benzyloxycarbonylamino)-5-bromo-2-p-tolylthiophene-3-carboxylate (176) in ethanol:ethyl acetate:dichloromethane (2:1:1). The mixture is degassed and placed under H2 (1 atm) and stirred for 4 h. The mixture is filtered through a 0.45 μm syringe filter and concentrated under reduced pressure. Flash chromatography (ISCO system, silica, 0-50% ethyl acetate in hexane) provides 177.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08618307B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-b5e8b89699914bfb834575c19ec040b3 |
| Source note | uspto-grants-2013_12 |