Lithium Hydroxide → HCID 51033466, compound

Participants

Reaction Steps

Ester 379 (1.45 g, 3.3 mmol) and lithium hydroxide (467 mg, 19.5 mmol) in tetrahydrofuran:methanol:water (3:2:1, 16 mL) was stirred at 50° C. for 1 h. The mixture was cooled in an ice bath and quenched with 2 M HCl (16 mL). The precipitate that formed was filtered off to provide 368 (1.40 g, 100%) as a solid: LRESIMS m/z 432.0 [M+H]+, calcd. for C20H13F3N3O3S1 432.1.

Provenance & Evidence