tert-Butanol → HCID 68089406, compound

Participants

Reaction Steps

A mixture of 5.6 g (17 mmol) rac-(3R,4R)-1-Benzyl-4-(4-chloro-phenyl)-3-methyl-pyrrolidine-3-carboxylic acid, 2.4 g (18.7 mmol) DIPEA and 5.14 g (18.7 mmol) diphenylphosphoryl azide in 120 mL tert.-butanol was heated to reflux over night. The mixture was concentrated under vacuum and purified by column chromatography on silica eluting with a gradient formed from heptane and ethyl acetate to yield after evaporation of the product containing fractions 4.63 g (68%) of the title compound as yellow viscous oil. MS m/e: 401.3 [M+H]+.

Provenance & Evidence